Finding Natural Compounds as Potential Inhibitors for Osteoarthritis

Osteoarthritis is the fourth leading cause of disability affecting more than 300 million people around globe. In this disease, chondrocytes responsible for growth and maintenance articular joints start to deplete due rogue involvement phosphoinositide 3-kinase, protein kinase-B p38 mitogenactivated kinases. Presently, there are medications providing symptomatic treatment, however, they cannot thwart progression osteoarthritis. Natural compounds can rejuvenate injured tissues, averting inflammation be useful treating The present study was conducted obtain inhibitors using natural 3-kinase/protein kinase-B/mitogenactivated kinases implicated in pathogenesis Results revealed that out 1541 compounds, cordycepin geraniol formed an inhibitory interaction with these Moreover, down regulated important inflammatory markers (DNA methyltransferase 1, cluster differentiation 74 ETS proto-oncogene 1) increased expression glutamate-cysteine ligase catalytic, FAM111 trypsin like peptidase A, secreted frizzled related 1 ferritin light chain genes survival chondrocytes. absorption, distribution, metabolism, excretion, toxicity lethal dose prediction studies showed has appropriate pharmacokinetics low acute level, whereas high level efficient pharmacokinetic profile. Our provided a preliminary insight capable kinase-B/mitogen-activated lead osteoarthritis therapy.